Bears Run for Connor Mansalis

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On November 19 a team from the Executive MBA class of 2018 is running the Berkeley Half Marathon to raise funds for a very important cause that directly affects the son of one of their classmates. Here is more about that cause from Kate Mansalis:

Connor Mansalis was born Sept 3, 2012 and was diagnosed with MECP2 Duplication Syndrome shortly after, when a respiratory arrest and feeding issues landed him in the neonatal intensive care unit at Children’s Hospital of Oakland. We had no idea what this diagnosis meant, and neither did the team of doctors who was caring for Connor. Through extensive internet searching, we came across the Rett Syndrome Research Trust (RSRT) and the 401 project. A non-profit made up of families of children with this diagnosis, the 401 project has raised over $1.2 million and is the largest single source of research funding for MECP2 Duplication. The progress that has been achieved so far has inspired us to join the fight in raising awareness and much needed funds for the very promising cures that are closer than ever. Please join us in supporting this work and donate in honor of Connor, who struggles every day against the hardships of the REVERSIBLE syndrome! Click here for more information.


Thank you!


What is MECP2 Duplication Syndrome?

Unlike Rett Syndrome, which is caused by mutations or deletions in the MECP2 gene, the symptoms that arise from the duplication syndrome are caused, as the name suggests, by having an area of the X chromosome (Xq28), which includes the MECP2 gene, erroneously duplicated. The section duplicated may vary from individual to individual and may also contribute to the severity of the disease.
The syndrome has been diagnosed mostly in boys. The majority inherits the duplication from their mothers who are typically asymptomatic due to favorable X chromosome inactivation (the moms have inactivated the X chromosome that harbors the duplication). Carrier mothers have a 50% chance of passing on the duplication to their children, meaning MECP2 Duplication Syndrome may be quite prevalent.

Learn more about MECP2 Duplication here.

What is the MECP2 Duplication Syndrome Fund at RSRT?

In an effort to immediately leverage RSRT's deep knowledge base and well established global scientific networks the MECP2 Duplication Syndrome Fund at RSRT was created in late 2010. The Fund puts the intellectual and scientific resources of RSRT immediately to work for the MECP2 Duplication/Triplication Syndrome community.
The Fund exclusively supports projects devoted to the study and means of treatment of MECP2 Duplication Syndrome. 100% of every dollar contributed is invested in research - not a single penny goes to overhead.
In 2012, a parent-driven effort was established to raise funds for the initial reversal experiments conducted at the Baylor College of Medicine. Families pledged to raise $401 to cover the cost of the experiments. The initiative was a success, and the 401 Project was born. All funds raised through the 401 Project initiative are directly deposited into the MECP2 Duplication Syndrome Fund at RSRT.

Learn more about RSRT here.

Supporters (64)

  1. Amelia Brinker  
    1 day ago
    $30
  2. Gary Mullaney 
    2 days ago
    $50
  3. Ronald Sasaki 
    3 days ago
    $260
  4. Susan, Mehmet, Ingrid, Mark 
    4 days ago
    $350
  5. Saileel Vijaykar 
    5 days ago
    $50
  6. Brian Wilkins 
    6 days ago
    $100
  7. Juliet Gardner 
    1 week ago
    $40
  8. Jeanne Ormsby 
    1 week ago
    $36
  9. Beth Leven 
    1 week ago
    $50
  10. Amy Davis 
    1 week ago
    $100
  11. Jessica LaBounty 
    1 week ago
    $100
  12. Sarah Brinker 
    1 week ago
    $50
  13. Gabriel Briscoe 
    1 week ago
    $100
  14. Ryan Evans 
    1 week ago
    $100
  15. Ryan Evans 
    1 week ago
    $100
  16. Beth Pollak 
    1 week ago
    $36
  17. Trevor Buehl 
    2 weeks ago
    $100
  18. Jonathan Wong 
    2 weeks ago
    $50
  19. Adam & Dorothee Howes 
    2 weeks ago
    $100
  20. Anonymous 
    2 weeks ago
    $25
  21. Ann and Brinker 
    2 weeks ago
    $100
  22. Ellie Wigodsky 
    2 weeks ago
    $25
  23. Zoe Hyatt 
    2 weeks ago
    $50
  24. Jean Brinker 
    2 weeks ago
    $50
  25. Kyle and Melissa Kutsche  
    2 weeks ago
    $100
  26. Karin Johnson 
    3 weeks ago
    $150
  27. Jim & Sus Griffin 
    3 weeks ago
    $50
  28. David Polzin 
    3 weeks ago
    $50
  29. Patricia Baerwald 
    3 weeks ago
    $1,000
  30. Jim Griffin 
    3 weeks ago
    $250
  31. Anonymous 
    3 weeks ago
    $100
  32. Kevin Nguyen 
    1 month ago
    $100
  33. Anonymous 
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    $200
  34. Kas Farsad 
    1 month ago
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  35. Anonymous 
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  36. Julia Hantman 
    1 month ago
    $290
  37. Neil Shah 
    1 month ago
    $25
  38. Laura Teclemariam 
    1 month ago
    $100
  39. Varun Bedi 
    1 month ago
    $350
  40. Anonymous 
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    $100
  41. Anonymous 
    1 month ago
    $50
  42. Naren Ramani 
    1 month ago
    $25
  43. Mohit Marwaha 
    1 month ago
    $250
  44. Lauren Burke 
    1 month ago
    $50
  45. sahar kleinman 
    1 month ago
    $100
  46. Maura ONeill 
    1 month ago
    $100
  47. Anonymous 
    1 month ago
    $100
  48. Wendi Chiong 
    1 month ago
    $20
  49. Neal Johnson 
    1 month ago
    $100
  50. Marcus Krauss 
    1 month ago
    $200
  51. Audrey Ng 
    1 month ago
    $100
  52. Mlika Katherine 
    1 month ago
    $100
  53. Jessica Truitt 
    1 month ago
    $30
  54. Saira George 
    1 month ago
    $100
  55. Lauren Pearcy 
    2 months ago
    $10
  56. Anonymous 
    2 months ago
    $50
  57. Anonymous 
    2 months ago
    $50
  58. Manoj Thomas 
    2 months ago
    $1,000
  59. Raymond Daly 
    2 months ago
    $15
  60. Ricardo Cornejo 
    2 months ago
    $500
  61. Kim Olson 
    2 months ago
    $100
  62. Martha scurr 
    2 months ago
    $10
  63. Camille Wall 
    2 months ago
    $25
  64. Gary Mullaney 
    2 months ago
    $50

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